Dr. Christopher deFilippi

  • McCord J, Newby LK, deFilippi CR. Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation "High-Sensitivity" Cardiac Troponin Assays to Diagnose Myocardial Infarction. Circulation. 2018 Jul 17;138(3):316-318
  • Beri N, Daniels LB, Jaffe A, Mueller C, Anand I, Peacock WF, Hollander JE, DeFilippi C, Schreiber D, McCord J, Limkakeng AT, Wu AHB, Apple FS, Diercks DB, Nagurney JT, Nowak RM, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. Copeptin to rule out myocardial infarction in Blacks versus Caucasians. Eur Heart J Acute Cardiovasc Care. 2018 May 1
  • Nowak R, Mueller C, Giannitsis E, Christ M, Ordonez-Llanos J, DeFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Jacobsen G, Dinkel C, Lindahl B. High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study. Biomarkers. 2017 Dec;22(8):709-714.
  • Kamel H, Bartz TM, Elkind MSV, Okin PM, Thacker EL, Patton KK, Stein PK, deFilippi CR, Gottesman RF, Heckbert SR, Kronmal RA, Soliman EZ, Longstreth WT Jr. Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study). Stroke. 2018 Mar 13
  • de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL Jr, Shah SJ, Levy D, Herrington DM, Larson MG, van Gilst WH, Gottdiener JS, Bertoni AG, Ho JE. Association of Cardiovascular Biomarkers with Incident Heart Failure with Preserved and Reduced Ejection Fraction. JAMA Cardiol. 2018 Jan 10
  • defilippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni MV, Lee H, Grinspoon S. Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS. 2018 Jan 23.
  • deFilippi C, Seliger S. The Cardiac Troponin Renal Disease Diagnostic Conundrum: Past, Present, and Future. Circulation. 2018 Jan 30;137(5):452-454.
  • deFilippi C, Christenson R, Joyce J, Park EA, Wu A, Fitch KV, Looby SE, Lu MT, Hoffmann U, Grinspoon SK, Lo J. Statin Effects on Myocardial Fibrosis Markers in People Living with HIV. J Acquir Immune Defic Syndr. 2018 Feb 6.
  • LaPar DJ, Likosky DS, Zhang M, Theurer P, Fonner CE, Kern JA, Bolling SF, Peters MN, Seliger SL, Christenson RH, Hong-Zohlman SN, Daniels LB, Lima JAC, de Lemos JA, Neeland IJ, deFilippi CR. "Malignant" Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Heart Assoc. 2018 Feb 8;7(4)
  • Bhambhani V, Kizer JR, Lima JAC, van der Harst P, Bahrami H, Nayor M, de Filippi CR, Enserro D, Blaha MJ, Cushman M, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Brouwers FP, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL Jr, Levy D, Herrington DM, van Gilst WH, Bertoni AG, Larson MG, de Boer RA, Gottdiener JS, Shah SJ, Ho JE. Predictors and outcomes of heart failure with mid-range ejection fraction. Eur J Heart Fail. 2017 Dec 11
  • Harrington JL, Ayers C, Berry JD, Omland T, Pandey A, Seliger SL, Ballantyne CM, Kulinski J, deFilippi CR, de Lemos JA. Sedentary Behavior and Subclinical Cardiac Injury: Results From the Dallas Heart Study. 2017 Oct 10;136(15):1451-1453
  • Fashanu OE, Heckbert SR, Aguilar D, Jensen PN, Ballantyne CM, Basu S Hoogeveen RC, deFilippi C, Cushman M, Folsom AR. Galectin-3 and VenousThromboembolism Incidence: The Atherosclerosis Risk in Communities (ARIC) Study. Res Pract Thromb Haemost. 2017 Oct;1(2):223-230.
  • Christenson RH, deFilippi CR. The troponin decision-point dilemma: The 99th percentile solution "do the best you can [with cardiac troponin] until you know better. Then when you know better, do better." Maya Angelou, poet, dancer, producer, playwright, director, author. Am Heart J. 2017 Aug; 190:132-134.
  • Gupta DK, Daniels LB, Cheng S, deFilippi CR, Criqui MH, Maisel AS, Lima JA, Bahrami H, Greenland P, Cushman M, Tracy R, Siscovick D, Bertoni AG, Cannone V, Burnett JC, Carr JJ, Wang TJ. Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2017 Jun 30
  • Nowak R, Müller C, Giannitsis E, Christ M, Ordonez-Llanos J, DeFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Jacobsen G, Dinkel C, Lindahl B. High Sensitivity Cardiac Troponin T in Patients Not Having an Acute Coronary Syndrome: Results from the TRAPID-AMI Study. Biomarkers. 2017 May 23:1-26
  • deFilippi CR, Seliger SL. A Multibiomarker Approach to Heart Failure Prognostication: A Work in Progress. JACC Heart Fail. 2017 Apr;5(4):265-267.
  • Seliger SL, Hong SN, Christenson RH, Kronmal R, Daniels LB, Lima JAC, de Lemos JA, Bertoni A, deFilippi CR. High-Sensitive Cardiac Troponin T as an Early Biochemical Signature for Clinical and Subclinical Heart Failure: MESA (Multi-Ethnic Study of Atherosclerosis). Circulation. 2017 Apr 18;135(16):1494-1505.
  • de Lemos JA, Ayers CR, Levine BD, deFilippi CR, Wang TJ, Hundley WG, Berry JD, Seliger SL, McGuire DK, Ouyang P, Drazner MH, Budoff MJ, Greenland P, Ballantyne CM, Khera A. A Multimodality Strategy for Cardiovascular Risk Assessment: Performance in Two Population-Based Cohorts. Circulation. 2017 Mar 30
  • McCord J, Cabrera R, Lindahl B, Giannitsis E, Evans K, Nowak R, Frisoli T, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, Mueller C; TRAPID-AMI Investigators. Prognostic Utility of a Modified HEART Score in Chest Pain Patients in the Emergency Department. Circ Cardiovasc Qual 2017 Feb;10(2).
  • Seliger SL, Hong SN, Christenson RH, Kronmal R, Daniels LB, Lima JA, de Lemos JA, Bertoni AG, deFilippi CR. High Sensitive Cardiac Troponin T as an Early Biochemical Signature for Clinical and Subclinical Heart Failure: The Multi-Ethnic Study of Atherosclerosis. Circulation. 2017 Feb 3.
  • Vasudevan A, Singer AJ, deFilippi C, Headden G, Schussler JM, Daniels LB, Reed M, Than MP, Birkhahn R, Smith SW, Barrett TW, Arnold W, Peacock WF, McCullough PA. Renal Function and Scaled Troponin in Patients Presenting to the Emergency Department with Symptoms of Myocardial Infarction. Am J Nephrol. 2017 Feb 14;45(4):304-309.
  • Dey S, Wang Y, Byrd RJ, Ng K, Steinhubl SR, deFilippi C, Stewart WF. Characterizing Physicians Practice Phenotype from Unstructured Electronic Health Records. AMIA Annu Symp Proc. 2017 Feb 10; 2016:514-523
  • Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, deFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AH, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. Necessity of hospitalization and stress testing in low risk chest pain patients. Am J Emerg Med. 2017 Feb;35(2):274-280
  • Kim F, Biggs ML, Kizer JR, Brutsaert EF, de Filippi C, Newman AB, Kronmal RA, Tracy RP, Gottdiener JS, Djoussé L, de Boer IH, Psaty BM, Siscovick DS, Mukamal KJ. Brain natriuretic peptide and insulin resistance in older adults. Diabet Med. 2017 Feb;34(2):235-238
  • deFilippi CR, Seliger SL. Obesity and Survival with Heart Failure: Still a Paradox. JACC Heart Fail. 2017 Jan;5(1):64-66
  • Tecson KM, Arnold W, Barrett T, Birkhahn R, Daniels LB, deFilippi C, Headden G, Peacock WF, Reed M, Singer AJ, Schussler JM, Smith S, Than MP, McCullough PA. Interpretation of positive troponin results among patients with and without myocardial infarction. Proc (Bayl Univ Med Cent). 2017 Jan;30(1):11-15
  • Singer AJ, Than MP, Smith S, McCullough P, Barrett TW, Birkhahn R, Reed M,Thode HC, Arnold WD, Daniels LB, de Filippi C, Headden G, Peacock WF. Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores. Am J Emerg Med. 2017 Jan 5.
  • deFilippi CR, Herzog CA. Interpreting Cardiac Biomarkers in the Setting of Chronic Kidney Disease.Clin Chem. 2016 Nov 3.
  • Maan A, Jorgensen NW, Mansour M, Dudley S Jr, Jenny NS, deFilippi C, Szklo M, Alonso A, Refaat MM, Ruskin J, Heckbert SR, Heist EK. Association Between Heat Shock Protein-60 and Development of Atrial Fibrillation: Results from the Multi-Ethnic Study of Atherosclerosis (MESA).Pacing Clin Electrophysiol. 2016 Nov 3.
  • DeFina LF, Willis BL, Radford NB, Christenson RH, deFilippi CR, de Lemos JA. Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort.J Am Heart Assoc. 2016 Nov 28;5(12).
  • Ng K, Steinhubl SR, deFilippi C, Dey S, Stewart WF. Early Detection of Heart Failure Using Electronic Health Records: Practical Implications for Time Before Diagnosis, Data Diversity, Data Quantity, and Data Density. Circ Cardiovasc Qual Outcomes. 2016 Nov;9(6):649-658.
  • Brutsaert EF, Biggs ML, Delaney JA, Djoussé L, Gottdiener JS, Ix JH, Kim F, Mukamal KJ, Siscovick DS, Tracy RP, de Boer IH, deFilippi CR, Kizer JR Longitudinal assessment of N-terminal pro-B-type natriuretic peptide and risk of diabetes in older adults: The cardiovascular health study.  2016 Oct;65(10):1489-97.
  • Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, DeFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AH, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. Necessity of hospitalization and stress testing in low risk chest pain patients. Am J EmergMed. 2016 Oct 29
  • deFilippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M, Church T, Espeland M, Krithevsky SB, Stafford R, Seliger SL; LIFE Study Group. Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention. Am Heart J. 2016 Sep;179: 151-6.
  • Deo R, Norby FL, Katz R, Sotoodehnia N, Adabag S, deFilippi CR, Kestenbaum B, Chen LY, Heckbert SR, Folsom AR, Kronmal RA, Konety S, Patton KK, Siscovick D, Shlipak MG, Alonso A. Development and Validation of a Sudden Cardiac Death Prediction Model for the General Population. 2016 Sep 13;134(11):806-16.
  • Parikh RH, Seliger SL, Christenson R, Gottdiener JS, Psaty BM, deFilippi CRSoluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community-Dwelling Population. J Am Heart Assoc.2016 Aug 1;5(8)
  • Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, deFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French J, Christenson R, Weiser S, Bendig G, Dilba P, Lindahl B; TRAPID-AMI Investigators. Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T. Ann Emerg Med. 2016 Jul;68(1):76-87.e4
  • Fitch KV, DeFilippi C, Christenson R, Srinivasa S, Lee H, Lo J, Lu MT, Wong K, Petrow E, Sanchez L, Looby SE, Hoffmann U, Zanni M, Grinspoon SK. Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals. 2016 Jun 14
  • Spahillari A, Mukamal KJ, deFilippi C, Kizer JR, Gottdiener JS, Djoussé L, Lyles MF, Bartz TM, Murthy VL, Shah RV. The association of lean and fat mass with all-cause mortality in older adults: The Cardiovascular Health Study.Nutr Metab Cardiovasc Dis. 2016 Jun 28  
  • Mueller-Hennessen M, Lindahl B, Giannitsis E, Biener M, Vafaie M, deFilippi CR, Christ M, Santalo-Bel M, Panteghini M, Plebani M, Verschuren F, Jernberg T, French JK, Christenson RH, Body R, McCord J, Dilba P, Katus HA, Mueller C; TRAPID-AMI Investigators. Diagnostic and prognostic implications using age- and gender-specific cut-offs for high-sensitivity cardiac troponin T - Sub-analysis from the TRAPID-AMI study. Int J Cardiol. 2016 Apr 15; 209:26-33.
  • Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, deFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French J, Christenson R, Weiser S, Bendig G, Dilba P, Lindahl B; TRAPID-AMI Investigators. Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction with High-Sensitivity Cardiac Troponin T. Ann Emerg Med.2016 Jan 8.
  • Bansal N, Katz R, Seliger S, DeFilippi C, Sarnak MJ, Delaney JA, Christenson R, de Boer IH, Kestenbaum B, Robinson-Cohen C, Ix JH, Shlipak MG. Galectin-3 and Soluble ST2 and Kidney Function Decline in Older Adults: The Cardiovascular Health Study (CHS). Am J Kidney Dis. 2016 Jan 29.
  • Marston NA, Shah KS, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Daniels LB, Hollander JE, Apple F, Nagurney J, Schreiber D, deFilippi C, Diercks D, Limkakeng A, Anand IS, Wu AH, Jaffe AS, Peacock WF, Maisel AS. Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial.Emerg Med J. 2016 Jan;33(1):23-9